摘 要: 目的 了解学龄儿童中β3-肾上腺素能受体(β3-AR) 基因氨基酸序列第64 位密码子上的色氨酸(Trp64Arg) 变异型的分布特点及其与肥胖的关系。方法 用限制性片段基因长度多态性法对177 名儿童进行了基因多态性检测,同时测量身高、体重。结果 变异型等位基因(C) 在被调查对象中出现的频率为01240 ,其中男童为01226 ,女童为01267 。肥胖女童中变异等位基因(C) 、Trp64Arg 变异基因型的出现频率明显高于正常体重者。有父母肥胖或有母亲肥胖的家庭中,女童出现Trp64Arg变异的频率分别为7013% ,7114%。具有Trp64Arg变异儿童的体重、BMI 明显较高,具有Trp64Arg 变异的女童发生肥胖的危险性为415 。结论 基因Trp64Arg变异在学龄儿童中有一定的分布,且以肥胖女童为多。
关键词:β3 - 肾上腺素能受体;变异;儿童;肥胖
Distribution of beta 3 - adrenergic receptor Trp64Arg mutation in school - aged children MO Bao - qing , L I Zhong ,ZHAO Yan. Department of N ut rition and Food Sciences of Nanjing Medical University ( Nanjing 210029 , China)
Abstract: Objective To learn the distribution feature of beta 3 - adrenergic receptor (β3-AR)Trp64Arg mutation in school-aged children in Nanjing and its relationship with childhood obesity. ethods β3-AR Trp64Arg mutation was de2 tected with the method of RFL P among 177 school ildren ,their height and weight were measured. Results The mutative C allee was 0. 24 for all the children ,0. 226 for boys and 0. 267 for girls. The frequency of C allee and the genotype Trp64Arg was higher in obese girls. The frequency of the genotype Trp64Arg was 70. 3 % ,71. 4 % for obese girls with obese parents or obese mothers.Body weight and BMI of the children withβ3 - AR Trp64Arg mutation were also higher. The risk for obesity in girls withβ3 - ARTrp64Arg mutation was 4. 5. Conclusion There was distribution ofβ3 - AR Trp64Arg mutation in school - aged children in Nanjing ,especially in obese girls. It may be related to obesity.
Key words:β3-AR ;mutation ;children ;obesity
关键词:β3 - 肾上腺素能受体;变异;儿童;肥胖
Distribution of beta 3 - adrenergic receptor Trp64Arg mutation in school - aged children MO Bao - qing , L I Zhong ,ZHAO Yan. Department of N ut rition and Food Sciences of Nanjing Medical University ( Nanjing 210029 , China)
Abstract: Objective To learn the distribution feature of beta 3 - adrenergic receptor (β3-AR)Trp64Arg mutation in school-aged children in Nanjing and its relationship with childhood obesity. ethods β3-AR Trp64Arg mutation was de2 tected with the method of RFL P among 177 school ildren ,their height and weight were measured. Results The mutative C allee was 0. 24 for all the children ,0. 226 for boys and 0. 267 for girls. The frequency of C allee and the genotype Trp64Arg was higher in obese girls. The frequency of the genotype Trp64Arg was 70. 3 % ,71. 4 % for obese girls with obese parents or obese mothers.Body weight and BMI of the children withβ3 - AR Trp64Arg mutation were also higher. The risk for obesity in girls withβ3 - ARTrp64Arg mutation was 4. 5. Conclusion There was distribution ofβ3 - AR Trp64Arg mutation in school - aged children in Nanjing ,especially in obese girls. It may be related to obesity.
Key words:β3-AR ;mutation ;children ;obesity
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